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Avost Plus

Travoprost USP + Timolol BP

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Description

This Sterile Ophthalmic Solution contains Travoprost and Timolol which reduce intraocular pressure (IOP) by complementary mechanisms of action. Travoprost is a prostaglandin analogue which reduces IOP by increasing trabecular outflow & uveoscleral outflow. Timolol is a non-selective beta adrenergic receptor blocker that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane stabilizing) activity. It lowers IOP by decreasing the formation of aqueous humor in the ciliary epithelium.

Each ml contains Travoprost USP 0.04 mg and Timolol Maleate BP equivalent to Timolol 5 mg.

This Sterile Ophthalmic Solution is indicated for the treatment of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are insufficiently responsive to single therapy with prostaglandin analogue or topical beta blocker.

Instill one drop in the conjunctival sac of the affected eye(s) once daily at about the same time each day, preferably in the evening.

The most frequently reported treatment-related side-effect was ocular hyperemia. Approximately 3% of patients discontinued treatment due to conjunctival hyperemia.

For ophthalmic use only. Patients should remove their contact lenses prior to instilling this preparation and should not insert their lenses until 15 minutes after instillation of the preparation.

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. It should not be used during pregnancy. Use in lactation: Caution should be exercised when it is administered to a nursing mother.

Studies have not been conducted.

Store at 2° – 25° C. No refrigeration required.

Contraindicated in patients who are hypersensitive to Travoprost, Timolol or any of the components of this preparation. Most frequently reported side effects are ocular hyperemia.

Each plastic dropper bottle contains 5 ml sterile eye drops.