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Axosin

Ceftriaxone Sodium USP

NAME STRENGTH PACK SIZE DOSAGE FORM
Axosin 250 IV 250 mg 1's IV injection
Axosin 500 IV 500 mg 1's IV injection
Axosin 1g IV 1 gm 1's IV injection
Axosin 2g 2 gm 1's IV injection
Axosin 250 IM 250 mg 1's IM injection
Axosin 500 IM 500 mg 1's IM injection
Axosin 1g IM 1 gm 1's IM injection

Description

Axosin (Ceftriaxone) is a board spectrum parenteral third generation cephalosporin antibiotic. The drug is highly resistant to bacterial beta-lactamase and has a good activity against many gram-positive and gram-negative aerobic and some anaerobic bacteria. It inhibits bacterial cell wall synthesis in a manner similar to that of penicillin.

Axosin 250 mg IM and IV: Each vial contains Ceftriaxone 250 mg as sterile Ceftriaxone Sodium USP. Axosin 500 mg IM and IV: Each vial contains Ceftriaxone 500 mg as sterile Ceftriaxone Sodium USP. Axosin 1g IM and IV: Each vial contains Ceftriaxone 1g as sterile Ceftriaxone Sodium USP. Axosin 2g IV: Each vial contains Ceftriaxone 2g as sterile Ceftriaxone Sodium USP.

Axosin (Ceftriaxone) is indicated for the treatment of the following major infections when caused by susceptible organisms: 1.Renal & urinary tract infection; 2.Lower respiratory tract infection particularly pneumonia; 3.Gonococcal infection; 4.Skin, soft tissue, bone & joint infection; 5.Bacterial meningitis; 6.Serious bacterial infection e.g. septicemia; 7.ENT infection; 8.Infection in cancer patients; 9.Prevention of postoperative infection; 10.Pre-operative prophylaxis of infection associated with surgery; 11.Typhoid fever.

Adult: It is usually given to adults in a dose of 1 to 2 gm daily as a once daily dose or in two divided doses depending on the type and severity of infection. In severe infection up to 4 gm daily may be given. A single intramuscular dose of 250 mg is recommended for the treatment of uncomplicated gonorrhoea in adult. For surgical prophylaxis in adults, single dose of 1 gm may be administered 0.5 to 2 hours prior to surgery. Children: Suggested doses for infants and children are 50 to 75 mg per kg body weight once a day; for severe infection up to 80 mg per kg body weight daily may be given. Neonates: The maximum dose should not exceed 50 mg per kg; intravenous doses in neonates should be given over 60 minutes. Duration of Therapy: The duration of therapy varies according to the course of the diseases be continued for a minimum of 48-72 hours after the patients has become a febrile or evidence of bacterial eradication has been obtained.

"Well tolerated, side effects are relatively infrequent, usually mild and transient. The most common side effects are gastro-intestinal consisting mainly of loose stool, diarrhoea, nausea, vomiting stomatitis and glossitis. "

"Its safety in human pregnancy has not been established. Therefore it should not be used in pregnancy unless absolutely indicated. Mothers receiving Ceftriaxone should not breast-feed. In severe renal impairment accompanied by hepatic insufficiency, dosage reduction is required."

"Its safety in human pregnancy has not been established. Therefore it should not be used in pregnancy unless absolutely indicated. Mothers receiving Ceftriaxone should not breast-feed."

"A possible disulfiram like reaction may occur with alcohol."

Store below 25˚C

"Ceftriaxone sodium should not give in patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants and in full- term infants during the first 6 weeks of life. "

"Axosin 250 mg IM Injection: 1 vial of 250 mg Ceftriaxone Injection and one ampoule of 2 ml 1% Lidocaine USP injection in a combipack. Axosin 500 mg IM Injection: 1 vial of 500 mg Ceftriaxone Injection and one ampoule of 2 ml 1% Lidocaine USP injection in a combipack. Axosin 1g IM Injection: 1 vial of 1gm Ceftriaxone Injection and one ampoule of 3.5 ml 1% Lidocaine USP injection in a combipack. Axosin 250 mg IV Injection: 1 vial of 250 mg Ceftriaxone Injection and one ampoule of 5 ml water for injection BP in a combipack. Axosin 500 mg IV Injection: 1 vial of 500 mg Ceftriaxone Injection and one ampoule of 5 ml water for injection BP in a combipack. Axosin 1g IV Injection: 1 vial of 1g Ceftriaxone Injection and one ampoule of 10 ml water for injection BP in a combipack. Axosin 2g IV Injection: 1 vial of 2g Ceftriaxone Injection and two ampoules of 10 ml water for injection BP. "