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Bactin

Ciprofloxacin USP

NAME STRENGTH PACK SIZE DOSAGE FORM
Bactin 250 250 mg 2X10 Tablet
Bactin 500 500 mg 3X10 Tablet
Bactin 750 750 mg 2X10 Tablet
Bactin POS 250 mg / 5 ml 60 ml Powder for suspension
Bactin IV 0.2% w/v 100 ml IV infusion

Description

Bactin (Ciprofloxacin) is a broad-spectrum synthetic quinolone antibacterial agent. It is active against most of the gram-negative aerobic barteria like Enterobacteriaceas & Pseudomonas aeruginosa and gram positive aerobic bacteria including penicillinase producing, penicillinase non-producing and Methicillin-resistant Staphylococci. The bactericidal action of Ciprofloxacin results from interfering with the enzyme DNA gyrase.

Bactin 250: Each tablet contains Ciprofloxacin 250mg as Ciprofloxacin Hydrochloride USP. Bactin 500: Each tablet contains Ciprolloxacin 500mg as Ciprofloxacin Hydrochloride USP. Bactin 750: Each tablet contains Ciprolloxacin 750mg as Ciprofloxacin Hydrochloride USP. Bactin POS:Each bottle contains powder for reconstitution of 60 ml suspension. Bactin IV Infusion: Each 100 ml solution contains Ciprofloxacin 200 mg as Ciprofloxacin Lactate USP.

Bactin is indicated for the management of single or mixed infections caused by two or more susceptible mirooraganisms. It can also be used against infections caused by organisms resistant to other antibiotics. Bactin is indicated for the treatment of the following infections. Gastrointestinal tract infection: Typhoid fever and infected diarrhoea. Urinary tract infection: Complicated and uncomplicated urethritis, cystitis, pyelonephritis, prostatitis and epididymitis. Respiratory tract infection: Pneumonia, acute and chronic bronchitis, cystic fibrosis, bronchiectasis and empyema. Skin and soft tissue infection: Wound infection, abscess, infected ulcer, cellulitis, infected burn, erysipelas and otitis externa. Severe systemic infection: Septicemia, bacteremia, infection in immunosuppressive patient with hematological or solid tumors. Biliary tract infection: Cholangitis, cholecystitis, empyema of the gall bladder. Eye, ear, nose and throat infection: Otitis media, sinusitis, mastoiditis and tonsillitis. Bone and joint infection: Osteomylitis and arthritis. Pelvic infection: Salpingitis, endometritis and pelvic inflammatory diseases. Abdominal infection: Peritonitis & intra-abdominal abscess. Gonorrhea: Urethral, rectal and pharyngeal gonorrhoea caused by beta-lactamase producing organisms or organisms moderately sensitive to penicillin.

Adult: The usual adult dose is 250-750 mg 12 hourly. Usual dosage schedule¬Typhoid Fever: 500 mg 12 hourly 7-14 days Infected Diarrhoea: 500 mg 12 hourly 5-7 days Chronic Salmonella Carriers: 500-750 mg 12 hourly 28 days Complicated UT!: 500 mg 12 hourly 3-5 days Uncomplicated UTI: 250 mg 12 hourly 3-5 days Respiratory Tract Infection: 500-750 mg 12 hourly 7-14 days Skin and Soft Tissue Infection: 500-750 mg 12 hourly 7-14 days Uncomplicated Gonorrhea: 250 mg single dose Uncomplicated Gonorrhea: 250 mg single dose Wound Infection: 500 mg 12 hourly 7-14 days Bone and Joint Infection: 500-750 mg 12 hourly 7-14 days Other Infection: 500.750 mg 12 hourly 7-14 days Adolescent and Children: Generally not recommended but where the benefit is more than potential risk, the dose should be 10-30 mgrkg/day depending upon the severity of Infection, administered in two divided doses.

Ciprofloxacin is generally well tolerated. Gastrointestinal disturbances like nausea, vomiting, diarrhoea, dyspepsia and abdominal pain; CNS disturbances e.g. dizziness, drowsiness, headache, tiredness, confusion. convulsion, skin rashes, pruritus and possible systemic reactions may occur. It has also been reported that joint pain, mild photosensitivity may occur and liver enzyme, serum bilirubin, creatinine levels may increase slightly after administration.

Ciprofloxacin should be used with great caution it patient with a known history of epilepsy or other factors, which predispose to seizure and convulsion. Patients should be advised to take Clprofloxacin two hours after meal. Patients should be advised not to take Antacid containing aluminium or magnesium concomitantly or within two hours after dosing and also requested to drink plenty of water.

Ciprofloxacin has been shown to cause arthropathy it immature annals and therefore its use during pregnancy is not yet recommended. It has been reported that Ciprofloxacin is secreted in milk during administration to nursing mother and is thus not also recommended yet.

Concurrent administration of Ciprofloxacin with Theophyline and Caffeine may potentiate the adverse effects of theophyline and caffeine. Antacid containing aluminium or magnesium may decrease the bioavailablllty of Clprofloxacin. Quinolones, including Ciprofloxacin, have been reported to enhance the effects of the oral anticoagulant Warfarin or its derivatives.

Store below 30° C. Protect from light and moisture. Keep away from children’s reach.

Ciprofloxacin is contraindicated in patients with a known history of hypersensitivity to it or any of its components and to other Quinolones.

Bactin 250 Tablet: Each Box contains 2 x 10's film-coated tablets in blister strip. Bactin 500 Tablet: Each Box contains 3 x 10's film-coated tablet's in Alu-Alu blister strip. Bactin 750 Tablet: Each Box contains 2 x 10's film-coated tablets in blister strip. Bactin POS: Each bottle contains powder for reconstitution of 60ml suspension. Bactin IV Infusion: Each box contains 1 bottle of 100 ml solution of Ciprofloxacin for IV Infusion.