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Cinamycin Plus Gel
Clindamycin Phosphate USP + Tretinoin USP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Cinamycin Plus||1.2% + 0.025%||15 gm||Gel|
Cinamycin Plus Gel is a combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin. Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents elongation of peptide chain by interfering with the peptidyl transfer, thereby suppressing bacterial protein synthesis. Clindamycin inhibits the activity of Propionibacterium acne as reduces the occurrence of acne. Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turn over thereby brings the comedones out.
Cinamycin Plus Gel: Each gram gel contains Clindamycin phosphate USP 12 mg and Tretinoin USP 0.25 mg.
Indications And Uses
Cinamycin Plus Gel is indicated for the the topical treatment of Acne vulgaris in patients 12 years or older.
Dosage And Administration
Before sleep: Wash the face gently with a mild soap and water, then pat the skin dry. Apply the Gel with finger tips through the face gently. In the morning: Apply a sunscreen after the application of Gel. Do not wash your face more than 2 or 3 times a day. Apply the sunscreen cream as needed.
Erythema, scaling, nasopharyngitis, dry skin, cough, sinusitis and diarrhea are the common side effects.
Clindamycin and Tretinoin should not be applied to eyes, nose, ear, lips, cut, burn and other infections. After the application of the Gel, keep away from sunlight.
Use In Pregnancy Lactation
Pregnancy Category C. It is not known whether Clindamycin or Tretinoin is excreted in human milk. Caution should be exercised when Gel is administered to a nursing woman.
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime) should be approached with caution. While using concomitantly with Erythromycin, the activity of both Clindamycin and Erythromycin are decreased. So, Clindamycin should not be used with Erythromycin concomitantly. While using concomitantly with neuromuscular medicine, the activity of the neuromuscular medicine is increased. So, care should be taken during these concomitant uses.
Store in a cool (below 25°c) and dry place away from light. Do not freeze.
Clindamycin and Tretinoin should not be administered to individuals who are hypersensitive to Clindamycin or Tretinoin or any other component of the Gel.
Each tube contains 15 gm Gel.