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|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Clarith||125 mg/ 5 ml||70 ml||Powder for suspension|
Clarithromycin is a macrolide antibiotic. It acts by inhibiting microsomal protein synthesis by binding to the 50S subunit of the bacterial ribosome. Clarithromycin is active against most gram-positive bacteria, Chlamydia, some gram-negative bacteria and Mycoplasmas.
Clarith Tablet: Each film coated tablet contains Clarithromycin USP 500 mg. Clarith Powder for Suspension: Each 5 ml suspension contains Clarithromycin USP 125mg.
Indications And Uses
Clarithromycin is indicated for- • LRTIs for example, acute and chronic bronchitis and pneumonia. • URTIs for example, sinusitis, pharyngitis and otitis media. • Skin and soft tissue infection
Dosage And Administration
Clarithromycin may be given with or without meals. Usual dose is 250 mg twice daily for 7 days. Dose may be increased to 500 mg twice daily if necessary in severe infections. a course is usually for 7 to 14 days. In patient with severe renal impairment dosage may need to be halved to 250 mg once daily or 250 mg twice daily in severe infection or as directed by a registered physician. Children: The usual recommended daily dosage is 15 mg/kg in 2 divided doses for 10 days.
Diarrhoea , nausea , abnormal taste , dyspepsia , abdominal pain/discomfort , headache .
Caution should be taken in patients with impaired hepatic and renal function.
Use In Pregnancy Lactation
Pregnancy Category C. Clarithromycin should not be used during pregnancy or lactation if possible.
The use of Clarithromycin who are receiving Theophylline may be associated with an increase of serum Theophylline concentrations. Concomitant administration of single dose of Clarithromycin and Carbamazepine has been shown to result in increased plasma concentration of Carbamazepine. Concomitant use of Clarithromycin with Cisapride, Pimozide or Terfenadine is contraindicated.
Stored in a cool and dry place below 30 ˚C. Keep away from light.
Hypersensitive to Clarithromycin, Erythromycin or any of the macrolide antibiotics.
Clarith Tablet: Each box contains 10 tablets in Alu-Alu blister pack Clarith powder for Suspension: Bottle contains dry powder for 70 ml suspension