Home / Products / Pharma / General / By Brand Name / Clovir
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Clovir 200||200 mg||3X10||Tablet|
|Clovir 400||400 mg||2X10||Tablet|
Clovir Acyclovir is a synthetic purine derivative which exerts its antiviral effect on herpes simplex virus (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. Pharmacologically it is inactive and only becomes activated as a virustatic agent after penetrating into a cell infected by virus. After activation the Acyclovir shows affinity to viral DNA polymerase, and thus selectively inhibits viral DNA polymerase enzyme activity leading to termination of viral DNA chain synthesis.
Clovir 200 Tablet: Each tablet contains Acyclovir BP 200 mg. Clovir 400 Tablet: Each tablet contains Acyclovir BP 400 mg.
Indications And Uses
Acyclovir is indicated for the initial treatment, prevention of recurrence of viral infections due to herpes simplex virus (type I & II) (eg. genital herpes, herpes labialis, keratoconjunctivitis, finger infection, primary stomatitis etc) and varicella-zoster virus (herpes zoster & chicken pox).Acyclovir is also indicated for the prophylaxis of herpes simplex infections in immunocompromised patients.Acyclovir is indicated for the treatment viral infections due to varicella-zoster virus (herpes zoster & chicken pox).
Dosage And Administration
Treatment of herpes simplex: i. Initial treatment: Adults: 200 mg 5 times daily usually for 5 days. For immunocompromised patients 400 mg 5 times daily for 5 days (longer if new lesions appear during treatment or if healing incomplete; increase dose to 800 mg 5 times daily for genital herpes in immunocompromised) or as directed by the registered physician.Children under 2 years : Half of the adult’s dose.Children over 2 years : Adult dose. ii. Prevention of recurrence:200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months.Children under 2 years : Half of the adult’s dose. Children over 2 years : Adult dose.iii. Prophylactic treatment of herpes simplex in the immunocompromised: Adults: 200 to 400 mg 4 times daily.Children under 2 years : Half of the adult dose.Children over 2 years : Adult dose.Treatment of varicella (chicken pox): Adult and children over 40 kg: 800 mg 4 times daily for 5 days.Children below 40 kg: 20 mg / kg (maximum 800 mg) per dose orally 4 times daily for 5 days.Or Children under 2 years : 200 mg 4 times daily. Children 2-5 years : 400 mg 4 times daily. Children Over 6 years : 800 mg 4 times daily. Treatment of herpes zoster (Shingles): 800 mg 5 times daily for 7 days.Treatment of initial rectal (Proctitis) herpes infections: 400 mg 5 times daily for 10 days or until clinical resolution occurs has been recommended.
Headache, neurological reactions, fatigue, rashes, gastro-intestinal disturbances, rises in bilirubin and liver-related enzymes, increases in blood urea and creatinine, decreases in hematological indices, headache, neurological reactions, and fatigue.
Acyclovir should be administered with caution to patient with renal impairment and doses should be adjusted according to creatinine clearance. Monitor neutrophil count at least twice weekly in neonates.
Use In Pregnancy Lactation
Pregnancy category B, There are no adequate and well-controlled studies of acyclovir use in pregnant women. So, the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. Aciclovir is excreted in breast milk. Acyclovir should be used with caution during lactation.
Concomitant administration of probenecid and Acyclovir has reportedly increased the mean plasma half-life and decreased urinary excretion and renal clearance of Acyclovir.
Acyclovir is contraindicated in patients known to be hypersensitive to Acyclovir.
Clovir 200 tablet: Each box contains 30 (3x10’s) tablets in Alu-Alu blister strips.Clovir 400 tablet: Each box contains 20 (2x10’s) tablets in Alu-Alu blister strips.