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Atorvastatin Calcium Trihydrate INN
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Atorvastatin is a selective, competitive inhibitor of 3-hydroxy-3-methylglutaryl- coenzyme A (HMG-CoA) reductase. This enzyme catalyses the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis particularly in the liver. By lowering the amount of cholesterol in the liver cells, atorvastatin increases the formation of receptors for LDL, and thereby reduces blood levels of total and LDL cholesterol. In addition to lowering LDL cholesterol, atorvastatin also modestly reduces triglyceride levels and raises HDL (the so-called "good") cholesterol.
Colostat-10 Tab: Each tab contains 10 mg Atorvastatin INN. Colostat-20 Tab: Each tab contains 20 mg Atorvastatin INN
Indications And Uses
Colostat is indicated in primary hypercholesterolaemia (familial or non-familial) or combined hyperlipidaemia in patients who have not responded adequately to diet and other appropriate measures.
Dosage And Administration
Primary hypercholesterolaemia and combined hyperlipidaemia : Usually 10 mg once daily with/ without food. Familial hypercholesterolaemia : Initially 10 mg daily, increased at intervals of 4 weeks to 40 mg daily.
Reversible myositis(rare), headache, altered liver function tests and gastro-intestinal effects including abdominal pain, nausea and vomiting; also insomnia, angioedema, anorexia, alopecia, impotence, chest pain, hypoglycemia etc.
Should be used with caution in patients with a history of liver disease or with a high alcohol intake. Liver function test should be carried out before and within 1-3 months of starting treatment. Treatment should be discontinued if serum transaminase concentration rises to and persist at 3 times the upper limit of the reference range.
Use In Pregnancy Lactation
Atorvastatin is contraindicated in pregnancy & breast feeding mother.
Atorvastatin is contraindicated in acute liver disease and in pregnancy & breast feeding mother.