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Fluticare

Fluticasone Propionate

NAME STRENGTH PACK SIZE DOSAGE FORM
Fluticare Ointment 0.005% w/w 10 gm Ointment
Fluticare Cream 0.05% w/w 10 gm Cream

Description

Fluticasone propionate is a glucocorticoid with high topical anti inflammatory potency, but a low HPA-axis suppressive activity after dermal administration. It, therefore, has a therapeutic index which is greater than most of the commonly available steroids. Fluticasone propionate has a high degree of selectivity for the glucocorticoid receptor. This receptor is believed to be responsible for the anti-inflammatory properties of glucocorticoids. Fluticasone propionate has weak affinity for the progesterone receptor, and virtually no affinity for the mineralocorticoid, estrogen, or androgen receptors. The therapeutic potency of glucocorticoids is related to the half life of the glucocorticoid-receptor complex. The half-life of the Fluticasone propionate glucocorticoid-receptor complex is approximately 10 hours.

Fluticare 0.05% cream: Each 10 mg of Fluticare Cream contains 0.005 mg of Fluticasone Propionate BP. Fluticare 0.005% ointment: Each 10 mg of Fluticare Ointment contains 0.0005 mg of Fluticasone Propionate BP.

Fluticareis indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive eczema/dermatitis.

Apply a thin layer of Fluticare cream to the affected skin areas once daily. Apply a thin layer of Fluticare ointment to the affected skin areas twice daily.

The fluticasone propionate preparations are usually well tolerated; local burning and pruritus have been reported. If signs of hypersensitivity appear, application should be stopped immediately. Prolonged and intensive treatment with potent corticosteroid preparations may cause local atrophic changes in the skin such as thinning, striae, dilatation of the superficial blood vessels, hypertrichosis and hypopigmentation. Secondary infection, particularly when occlusive dressings are used or when skin folds are involved and allergic contact dermatitis have also been reported with corticosteroid use. Exacerbation of the signs and symptoms of the dermatoses have been reported with corticosteroid use. Prolonged use of large amounts of corticosteroids, or treatment of extensive areas, can result in sufficient systemic absorption to produce the features of hypercorticism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. In infants, the napkin may act as an occlusive dressing.

Prgenancy Category-C

No information is available.

Acute over dosage is very unlikely to occur, however, in case of chronic over dosage or misuse the features of hypercorticism may appear, and in this situation, as with any corticosteroid, application should be discontinued. Over dosage by ingestion of Fluticasone propionate cream or ointment is extremely unlikely to occur due to the very low oral bioavailability of Fluticasone propionate.

Store below 30˚C. Do not freeze

Fluticasone propionate is contraindicated in Rosacea, Acne vulgaris, Perioral dermatitis, Primary cutaneous viral infections, Hypersensitivity to any of the ingredients, Perianal and genital pruritus, etc. The use of Fluticasone propionate is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria anddermatoses in children less than one year of age, including deramtitis and napkin eruptions.

Fluticasone propionate has a very low propensity for systemic absorption, nevertheless, prolonged application of high doses to large areas of body surface, especially in infants and small children might lead to adrenal suppression. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. The face, more than other areas of the body, may exhibit atropic changes after prolonged treatment with potent topical corticosteroids. This must be borne in mind when treating severe eczema. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions induced by occlusive dressing, and so the skin should be cleansed before a fresh dressing is applied.

Fluticare 0.05% Cream: Tube containing 10 gm of the cream. Fluticare 0.005% Ointment: Tube containing 10 gm of the ointment