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Ketotifen Fumarate INN
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Ketof||1 mg / 5 ml||100 ml||Syrup|
Ketof is a preparation of ketotifen which has antihistaminic and anti-anaphylactic activity. It has been used similarly to sodium chromoglycate in the prophylactic treatment of asthma.
Ketof Tablet: Each tablet contains 1.38mg ketotifen Fumarate BP equivalent to 1.00 mg ketotifen. Ketof Syrup: Each 5 ml of Syrup contains 1.38mg ketotifen Fumarate BP equivalent to 1.00 mg ketotifen.
Indications And Uses
Prophylactic management or treatment of bronchial asthma and symptomatic treatment of allergic conditions including rhinitis and conjunctivitis.
Dosage And Administration
Adult: 1mg (1 tablet or 1 teaspoonful) of ketotifen twice daily with food. In severe cases the dose may be doubled. 0.5 mg to 1 mg at night may be preferable for the first few days of treatment if drowsiness is likely to be a problem. Children (6 months t 3 years): 0.05 mg (0.25ml Syrup) per kg body weight given twice daily. Use in elderly: Same as adult dose or as advised by the physician.
Sedation, drowsiness associated with occasional dry mouth, slight dizziness may occur at the beginning of treatment but usually disappears with continuous use. CNS stimulation and weight gain also reported.
Treatment with existing antiasthmatic treatment should be continued for at least 2 weeks after initiation of ketotifen treatment due to the risk of exacerbation of asthma. For the same reason, ketotifen should be discontinued gradually over a period of 2-4 weeks. Drowsiness may occur, particularly during the first days of treatment. Patients should be warned not to drive or operate machinery until the effect of treatment on the individual is known. Ketotifen may also potentiate the effect of sedatives, hypnotics, antihistamines and alcohol. For this reason patients should be advised to avoid alcoholic drinks.
A reversible fall in the platelet count has been observed in a few patients receiving ketotifen concomitantly with oral antidiabetic agents and it has been suggested that this combination should therefore be avoided. Although there is no evidence of any teratogenic effect, recommendations for ketotifen in pregnancy or when breast feeding can not be given.
Ketof Tablet: Each box contains 10 x 10’s tablets in blister strip. Ketof Syrup: Bottle contains 100 ml ketotifen Fumarate syrup.