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Ambroxol Hydrochloride BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Lytex 100||15 mg / 5 ml||100 ml||Syrup|
|Lytex 15||6 mg / ml||15 ml||Paediatric drops|
|Lytex SR||75 mg||6X5||Capsule|
Ambroxol is a metabolite of Bromhexine. It has been proven that it possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretion) properties. Ambroxol stimulates the serous cells of the glands of the mucus membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. It stimulates production of phospholipids of surfactant by alveolar cells. Ambroxol has ant-inflammatory porperties. In patient with COPD, it imporves airway patency. Ambroxol also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.
Lytex Syrup: Each 5 ml of syrup contains Ambroxol hydrochloride BP 15 mg. Lytex Paediatric Drops : Each ml drop contains Ambroxol hydrochloride BP 6 mg. Lytex SR Capsule: Each capsule contains Ambroxol hydrochloride BP 75 mg.
Indications And Uses
Acute and chronic disease of respiratory tracts associated with viscid mucous including Acute & chronic bronchitis. Productive cough, Inflammatory diseases of Rhinopharyngeal tract, Asthmatic bronchitis, Bronchial asthma with thick expectoration, Bronchiectasis, chronic pneumonia.
Dosage And Administration
Lytex Paediatric Drops: Age 0-6 months old- 0.5 ml 2 times a day, 6-12 months old 1 ml 2 times a day, 1-2 years old 1.25 ml 2 times a day. Lytex Syrup: Age 2-5 years old 2.5 ml (1/2 teaspoonful) 2-3 times a day, 5-10 years old 5 ml (1 teaspoonful) 2-3 times a day, 10 years old and adults 10 ml (2 teaspoonful) 3 times a day. Lytex SR Capsule: Age 12 years old and adults 1 Capsule once daily.
Gastrointestinal side effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic response such as eruption, urticaria or angioneurotic edema may occur.
Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Use In Pregnancy Lactation
Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use during pregnancy, especially in the 1st trimester. Lactation: Safety during Lactation has not yet been established.
Ambroxol has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary infection). But Ambroxol should not be taken simultaneously with antitussive (e.g. Codeine) because mucus, which has been liquefied by Ambroxol, might not be expectorated.
Lytex Syrup: Each Bottle contains 100 ml syrup and a measuring spoon. Lytex Paediatric Drops: Each Bottle contains 15 ml paediatric drops and a calibrated dropper. Lytex SR Capsule: Each Box contains 6 x 5 's capsules in blister pack.
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.