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Sulphadoxine BP + Pyrimethamine BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Malex||500 mg + 25 mg||5X6||Tablet|
Malex (Sulphadoxine & Pyrimethamine) is an antimalarial agent which acts by reciprocal potentiating of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites. The components of Malex are both orally absorbed and excreted mainly by the kidneys.
Malex Tablet: Each tablet contains Sulphadoxine BP 500 mg & Pyrimethamine BP 25 mg.
Indications And Uses
Malex is indicated in the treatment of acute malarial attack particularly caused by Plasmodium falciparum. Also, Malex is indicated for prophylactic management to the travellers in the area where resistant to Chloroquine is endemic. Unlabeled uses: Malex can be used as a prophylactic agent for the prevention of Pneumocystis carinii pneumonia in patients with AIDS usually as a second line agent.
Dosage And Administration
Recommended Dosage to be administered as: Adult: Over 14 years of age: 2-3 tablets as a single dose; Child under 4 years: ½ tablet; age 4-8 years: 1 tablet; 9-14 years: 2 tablets; All as single dose. Prophylaxis: Over 14 years: 1 tablet weekly, Child under 4 years: ¼ of adult dose; 4-8 years: ½ of adult dose; 9-14 years: ¾ of adult dose.
Side effects are hypersensitivity reaction, some haematologic symptoms, GIT symptoms and CNS Symptoms.
Periodic blood counts should be performed and urine should be analyzed for crystalluria during prolonged prophylaxis. Also, the drug should be administered cautiously to patients with possible folate deficiency, severe allergy or bronchial asthma.
Malex is contraindicated in patients hypersensitive to Sulphadoxine or Pyrimethamine with documented megaloblastic anaemia due to folate deficiency, infants under 2-months of age, pregnancy at term and during the nursing period, prophylactic use in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias.
Malex Tablet: Box contains 30 (5x6's) tablets in Aluminium strip.