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Naproxen USP + Esomeprazole BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Nupralgin Plus 375||375 mg + 20 mg||3X10||Tablet|
|Nupralgin Plus 500||500 mg + 20 mg||3X10||Tablet|
Nupralgin Plus is the preparation of Naproxen and Esomeprazole. Nupralgin Plus tablet is indicated for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients. Nupralgin Plus is Available as 375 & 500 mg tablet.
Nupralgin Plus 375 tablet: Each delayed release tablet contains Naproxen USP 375 mg and Esomeprazole Magnesium Trihydrate BP Equivalent to Esomeprazole 20 mg. Nupralgin Plus 500 tablet: Each delayed release tablet contains Naproxen USP 500 mg and Esomeprazole Magnesium Trihydrate BP Equivalent to Esomeprazole 20 mg.
Indications And Uses
Nupralgin Plus tablet is indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAlDs-associated gastric ulcers.
Dosage And Administration
Carefully consider the potential benefits and risks of Nupralgin Plus and other treatment options before deciding to use Nupralgin Plus. Use the lowest effective dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be consider. Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis and dysmenorrhoea, Nupralgin Plus 375 & 500: 1 Tablet twice daily. Do not split, chew, crush or dissolve the tablet. Nupralgin Plus is to be taken at least 30 minutes before meals.
The adverse effects reported with this combination may include gastrointestinal disorders like dyspepsia, diarrhea, nausea, flatulence, abdominal pain etc.
Use In Pregnancy Lactation
Use in Pregnancy: Pregnancy category C. In late pregnancy, it should be avoided because it may cause premature closure of the ductus arteriosus. Use in lactating mothers: Naproxen & Esomeprazole are likely to be excreted in human milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Several studies have shown no interaction between the two components Naproxen and Esomeprazole. NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. Probenecid increases Naproxen anion plasma levels and extends its plasma half-life significantly. Co-administration of oral contraceptives, diazepam, phenytoin or quinidine does not seem to change the pharmacokinetic profile of Esomeprazole.
Store in a cool & dry place, protect from light. Keep out of the reach of children.
This combination is contraindicated in patients with known hypersensitivity to Naproxen, Esomeprazole Magnesium or to any of the component. This combination is contraindicated in patients who have experienced asthma, urticaria or allergic reactions after taking aspirin or other NSAlDs. This combination is also contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery and in patients in the late stage of pregnancy.
Nupralgin Plus 375 tablet: Each box contains 3x10's tablets in Alu-Alu blister pack. Nupralgin Plus 500 tablet: Each box contains 3x10's tablets in Alu-Alu blister pack.