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Oxiflam is the preparation of Tenoxicam. Oxiflam is an anti-inflammatory drugs and indicated for the treatment of Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Post-operative pain etc.
Oxiflam tablet: Each film coated tablet contains Tenoxicam BP 20 mg.
Indications And Uses
Oxiflam is indicated for the symptomatic treatment of the following painful, inflammatory and degenerative disorders of the musculoskeletal system: • Rheumatoid arthritis • Osteoarthritis • Ankylosing spondylitis • Extra-articular disorders, e.g. tendinitis, bursitis, periarthritis of shoulders (shoulder-hand syndrome) or hips, strains and sprains • Post-operative pain • Acute gout • Primary dysmenorrhoea
Dosage And Administration
For all indications except primary dysmenorrhoea, postoperative pain and acute gout,a daily dosage of 20 mg should be given at the same time of day. The recommended dose for primary dysmenorrhoea is 20 to 40 mg once daily. For post-operative pain the recommended dose is 40 mg once daily up to five days and for acute attacks of gout the recommended dose is 40 mg once daily for two days followed by 20 mg once daily for a further five days. For patients needing long-term treatment a reduction to a daily oral dose of 10 mg may be tried for maintenance. The tablet should be taken with a glass of water. It is preferable to lake this medicine during or immediately after a meal. Children: No dosage recommendations have so far been established.
Tenoxicam proved to be well tolerated in the recommended dose. Usually the undesirable effects reported were mild and transient. The following undesirable effects have been reported: Frequency greater than 1%: Gastrointestinal tract: gastric, epigastric and abdominal discomfort, dyspepsia, heartburn, nausea. Central nervous system: dizziness, headache. Frequency less than 1%: Gastrointestinal tract: constipation, diarrhea, stomatitis, gastritis, vomiting, ulcers, GI-bleeding. Central nervous system: fatigue, sleep disturbances, appetite loss, dry mouth, vertigo. Skin: itching, erythema, exanthema, rash, urticaria. Urinary tract and kidneys: increase in BUN or creatinine, edema. Liver and biliary tract: increased liver enzyme activity. Cardiovascular system: palpitations.
Use In Pregnancy Lactation
NSAIDs have an inhibitory effect on prostaglandin synthesis and, when given during late pregnancy, may cause closure of the fetal ductus arteriosus, prolong labor and delay parturition. Treatment during the third trimester of pregnancy should be avoided. There is no evidence of adverse reactions in breastfed infants of mothers taking Tenoxicam. Nevertheless, infants should be weaned or the drug discontinued.
Tenoxicam may have the following drug interactions: Acetylsalicylate and Salicylates: Salicylates increase the clearance and volume of distribution of NSAIDs including Tenoxicam. Anti-platelet agents and SSRls: There is an increased risk of gastrointestinal bleeding when anti-platelet agents and selective serotonin-reuptake inhibitors (SSRls) are combined with NSAIDs Methotrexate : Caution should be exercised if NSAIDs and Methotrexate are administered within 24 hours of each other, since NSAIDs may increase Methotrexate plasma levels, resulting in increased toxicity. Diuretics and antihypertensives: No clinically significant interaction between Tenoxicam and Frusemide was noted, but Tenoxicam attenuates the blood pressure lowering effect of Hydrochlorothiazide. As known from other NSAIDs, Tenoxicam might attenuate the antihypertensive effects of alpha-adrenergic blockers and ACE-inhibitors.
Store in cool and dry place. Protect from light and moisture. Keep the medicine out of the reach of children.
Tenoxicam is contraindicated in patients with known hypersensitivity to Tenoxicam or any component of the product or other non-steroidal anti-inflammatory drugs (NSAIDs); in whom salicylates or other non-steroidal antiinflammatory drugs (NSAIDs) induce symptoms of asthma, rhinitis or urticaria; suffering or having suffered from disease of the upper gastrointestinal tract, such as gastritis, gastric and duodenal ulcer.
Oxiflam tablet: Each box contains 30's tablets in alu-alu blister pack.