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Cephradine + Arginine BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Sinaceph DS||250 mg / 5 ml||100 ml||Powder for suspension|
|Sinaceph 500||500 mg||1's||IV/IM injection|
|Sinaceph 1g||1 gm||1's||IV/IM injection|
|Sinaceph 15||125 mg/1.25 ml||15 ml||Paediatric drops|
|Sinaceph 250||250 mg||4X5||Capsule|
|Sinaceph 500||500 mg||3X10||Capsule|
|Sinaceph 100||125 mg/ 5 ml||100 ml||Powder for suspension|
Sinaceph (Cephradine) is a sernisynthetic: broad spectrum bactericidal antibiotic. It is active against infections caused by both gram-positive and grain negative microorganisms. Both penicillinase-producing and nonproducinq staphylococci are sensitive to Sinaceph. The main site of action of Sinaceph is the cell wall of bacteria. Cell wall of sensitive organism contains peptidoglycan. Sinaceph inhibits cross-linking process and as a result cell wall with many pores is formed, thus lysis of bacteria occurs due to external osmotic pressure.
Sinaceph Capsule: Each capsule contains Cephradine BP 250 mg / 500 mg. Sinaceph Suspension: After reconstitution each 5 ml suspension contains Cephradine BP 125 mg. Sinaceph DS Suspension: After reconstitution each 5 ml suspension contains Cephradine BP 250 mg. Sinaceph Paediatric drops: After reconstitution each ml suspension contains Cephradine BP 100 rng. Sinaceph Injection: Each vial contains Cephradine BP 500 mg / 1 gm.
Indications And Uses
Sinaceph is indicated for the following diseases: Skin and soft tissue infection: Abscess.cellulitis, furunculosis. Impetigo. Urinary tract infection: Cystitis, urethritis, pyelonephritis. Upper and lower respiratory tract infection: Pharyngitis, sinusitis, otitis media, tonsIlitis, acute and chronic bronchitis, lobar and bronchopneumonia. Gastrointestinal infection: Bacillary dysentery, enteritis, peritonitis. Genital infection, Bones and joint infection, Nose, ear and throat infection, Post operative infection and infections caused by sensitive microorganism of Cephradine.
Dosage And Administration
Oral: Adult: For respiratory and soft tissue infections in adults, the usual dose, is 250 oar 500 mg four times daily. For urinary tract infection, the usual dose is 500 mg four tunes daily. For gastrointestinal infection, the usual dose is 500 mg three to four times daily. Up to 1 gm four times daily may be given for severe or chronic infection, Children: The usual dose is 25-50 mg/kg/day given in 2 to 4 equally divided doses. For the treatment of otitis media the dose is 75-100 mg/kg daily in 2 to 4 equally divided doses The total daily dose should not exceed 4 gm. Parenteral: Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis, a single preoperative dose of 1-2 gm intramuscularly or intravenously is given. Children: The dose is 50-100 mg/kg daily in four equally divided doses. up to 300 mg/kg daily in severe infection.
Nausea, vomiting, diarrhoea and abdominal discomfort may occur.
Give cautiously to penicillin sensitive patients as there is evidence of partial cross-atlergenicity between the Cephalosporin and patients with markedly impaired renal function. Cephalosporin is excreted in breast milk and should be given with caution in lactating mothers.
Cephradine is contraindicated to patients who are hypersensitive to Cephalosporin group of antibiotics .
Sinaceph 250 Capsule : Box contains 20 capsules in blister pack. Sinaceph 500 Capsule : Box contains 30 capsules in blister pack. Sinaceph Suspension : Bottle contains dry powder for 100 ml suspension. Sinaceph DS Suspension : Bottle contains dry powder for 100 ml suspension. Sinaceph Paediatric Drops : Bottle contains dry powder for 15 mi suspension. Sinaceph 500 mg Injection : Box contains one vial Cephradine BP 500 mg, 5ml water for infection. Sinaceph 1 gm Injection : Box contains one vial Coohradine BP 1 gm and 10 ml water for injection.