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Tobramycin USP + Dexamethasone BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Tomycin-D ED||0.3% w/v + 0.1% w/v||5 ml||Eye drops|
|Tomycin-D EO||0.3% w/w + 0.1% w/w||3.5 gm||Eye ointment|
Tomycin-D eye drops (Tobramycin & Dexamethasone) ia a antibiotic+Steroid combination preparation. Used in superficial ocular infection and its adnexa like conjunctivitis, blepharitis etc & also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns or penetration of foreign bodies. tomycin-D is available as 5 ml sterle eye drops and 3.5 gm sterile eye ointment.
Tomycin-D eye drops: Each ml contains Tobramycin USP 3 mg & Dexamethasone USP 1 mg. Tomycin-D eye ointment: Each gram contains Tobramycin USP 3 mg & Dexamethasone USP 1 mg.
Indications And Uses
Superficial ocular infection and its adnexa like conjunctivitis, blepharitis, blepharo-conjunctivitis, keratitis, corneal ulcer caused by susceptible bacterial organism; Where risk of superficial ocular infection is high; Or there is an expectation that potentially dangerous number of bacteria will be present in the eye. Ocular steroid in this combination produces prompt action in inflammatory conditions palpebral and bulber conjunctiva, cornea and anterior segment of the globe to obtain diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns or penetration of foreign bodies.
Dosage And Administration
In mild to moderate infections, instill one drops into the affected eyes every 4 hours during 1-2 days. In severe infections, instill 1 drop into the eyes hourly until improvement. Not more than 20 ml should be prescribed at a time.
The reactions due to Tobramycin are localized ocular toxicity and hypersensitivity, including lid itching and swelling and conjunctival erythema, in case of 4% patients found only. The reactions due to steroid component are elevation of intraocular pressure, posterior subcapsular cataract formation and delayed wound healing.
Prolonged use may result in overgrowth of non-susceptible organisms including fungi. If superinfections occurs, appropriate therapy should be initiated. If hypersensitivity develops discontinue use and initiate appropriate therapy.
Use In Pregnancy Lactation
Corticosteroids have been found teratogenic in animal studies. If maximum dose is given and complete systemic absorption occurs, which is highly unlikely the daily dose of Dexamethasone would be 2.4 mg. Reproduction sutdies of Tobramycin in rat revealed no evidence ot impaired fretility or harm to the fetus. Tomycin-D eye drops should be used during pregnancy only if potential benefit justifies the potential risk to the fetus. Nursing mother: Systemically administered corticosteroid may appear into the human milk and could suppress growth, interfere with endogenous corticosteroid production or cause untoward effects. But it is not known whether topical administration of corticosteroid could result sufficient systemic absorption to produce detectable quantity in human milk. Tobramycin is not absorbed from GIT so it cannot go in the systemic circulation of nursing babies. Special caution should be taken when Tomycin-D eye drops is administered to a nursing woman.
Viral infection, fungal infection, mycobacterial infection and known hypersensitivity to any of the component of this combination.
Eye Drops: Dropper bottle contains 5 ml strile eye drops. Eye Ointment: Each tube contains 3.5 gm ointment