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Bambuterol HCl BP
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Venterol 60||5 mg/5 ml||60 ml||Syrup|
|Venterol 10||10 mg||10X10||Tablet|
|Venterol 20||20 mg||5X10||Tablet|
Bambuterol is an adrenergic ß2 receptor agonist which predominantly stimulates ß2 receptor, thus producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators & increased mucocilliary clearance.
Venterol Tablet 10 mg: Each tablet contains bambuterol hydrochloride BP 10 mg. Venterol Tablet 20 mg: Each tablet contains bambuterol hydrochloride BP 20 mg. Venterol Syrup: Each ml syrup contains bambuterol hydrochloride BP 1 mg.
Indications And Uses
Bronchial asthma, chronic bronchitis, emphysema & other lung diseases where bronchospasm is a complicating factor.
Dosage And Administration
♦ Children 2-5 years: The recommended normal dose 10 mg (10 ml syrup). ♦ Children 6-12 years: The recommended normal dose 10 mg (10 ml syrup). The dose may be increased to 20 mg. ♦ Adult: The recommended initial dose 10 mg. The dose may be increased to 20 mg after 1-2 weeks depending on the clinical effect.
Fatigue, nausea, palpitation, headache, dizziness & tremor.
Dose should be reduced in patients with severely impaired renal function, patiens
Use In Pregnancy Lactation
Although no teratogenic effects have been observed in animal after administration of bambuterol, caution is recommended during first trimester of pregnancy. It is not known whether bambuterol or intermediary metabolites pass over to breast milk, so caution is recommended if bambuterol is administered to patients who are breast feeding. Terbutalin passes over to breast milk but an influence on the child is unlikely with therapeutic doses. Transient hypoglycemia has been reported in new born pre-term infants after maternal ß2 agonist treatment.
Succinylcholin, MAOIs (monoamine oxidase inhibitors), ß2-blockers, corticosteroids, diuretics, muscle relaxants, sympathomimetic xanthine derivatives.
No case of bambuterol overdosage has yet been reported in human. It is likely that overdosing would result in high levels of terbutaline & therefore the same symptoms & signs may include: headache, anxiety, tremor, nausea, tonic muscle cramps, palpitations, tachycardia & cardiac arrythmias. A fall in blood pressure sometimes occurs after terbutaline overdosage. Laboratory findings: hyperglycaemia and lactacidosis sometimes occur. High doses of ß2-agonists may cause hypokalemia as a result of redistribution of potassium.
Hepatic impairment, liver cirrhosis or severely impaired liver function.
Venterol Tablet 10 mg: Each box contains 100 tablets in blister strip. Venterol Tablet 20 mg: Each box contains 50 tablets in blister strip. Venterol Syrup: Each bottle contains 60 ml syrup.