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Levosalbutamol Sulphate INN
|NAME||STRENGTH||PACK SIZE||DOSAGE FORM|
|Ventisal-L 100||1 mg / 5 ml||100 ml||Syrup|
|Ventisal-L 50||1 mg / 5 ml||50 ml||Syrup|
|Ventisal-L 2||2 mg||10X10||Tablet|
Levosalbutamol is a single isomer β2 agonist that differs from racemic salbutamol by elimination of (S)-salbutamol. Levosalbutamol is an effective bronchodilator whose primary mechanism of action is unimpeded by (S)-salbutamol. Thus, when compared with racemic salbutamol, clinically comparable bronchodilation can be achieved with doses that substantially lessen beta-mediated side effects.
Ventisal-L Tablet: Each tablet contains Levosalbutamol Sulphate INN equivalent to Levosalbutamol 2 mg. Ventisal-L Syrup: Each 5 ml syrup contains Levosalbutamol Sulphate INN equivalent to Levosalbutamol 1 mg.
Indications And Uses
Levosalbutamol (Ventisal-L) is indicated for the treatment & prevention of bronchospasm in adults, adolescents, and children 6 years of age and older with reversible obstructive airway diseases.
Dosage And Administration
Adults and adolescents above 12 years : 1-2 mg (5 -10 ml), three times daily. Children (6-11 years) : 1mg (5 ml), three times daily.
Potentially serious hypokalemia may result from β2 agonist therapy. This effect may be potentiated by hypoxia. Other side effects such as palpitation, fine tremors of the skeletal muscle (particularly the hand) and muscle cramps may occur. The other likely side effects are gastrointestinal disturbances such as nausea, vomiting, burning substernal or epigastric pain and diarrhoea. In some cases nervousness, headache, dizziness, fatigue and sleeplessness may occur.
Particular caution is advised in acute severe asthma as this effect may be potentiated by hypoxia and by concomitant treatment with xanthine derivatives, steroids and diuretics. Serum potassium levels should be monitored in such situations. Oral Levosalbutamol should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias or hypertension.
Use In Pregnancy Lactation
In Pregnancy: The drug should be used during pregnancy only if the expected benefit to the mother is greater than any possible risk to the fetus or the infant. In Lactation: It is not known whether Levosalbutamol is excreted in human milk. Caution should be exercised when oral Levosalbutamol is administered to a nursing woman.
Levosalbutamol is contraindicated in patients with a history of hypersensitivity to this compound or any of the components of this formulation.
Other short-acting sympathomimetic bronchodilators or epinephrine should be used with caution with Levosalbutamol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.
The expected symptoms with overdose are those of excessive beta-adrenergic stimulation symptoms listed under side effects. In the event of serious poisoning, the stomach should be emptied and, if necessary, a beta-blocker administered with caution in patients with a history of bronchospasm.
Ventisal-L Tablet: Each box containing 10 x10's tablets in blister strip. Ventisal-L 50 ml Syrup: Each bottle contains 50 ml syrup with a spoon. Ventisal-L 100 ml Syrup: Each bottle contains 100 ml syrup with a spoon.