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Xofyl
Doxophylline INN
| NAME | STRENGTH | PACK SIZE | DOSAGE FORM |
|---|---|---|---|
| Xofyl 400 mg | 400 mg | 3X10 | Tablet |
| Xofyl 200 mg | 200 mg | 5X10 | Tablet |
Description
Doxophylline is a new generation xanthine derivative which has a dioxolane group at N-7 position of its chemical structure. Doxophylline inhibits phosphodiesterase activities. Moreover, Doxophylline appears to have a less affinity towards adenosine A1 and A2 receptors which is account for the better safety profile of the drug. Doxophylline also inhibits platelet activating factor and the generation of leukotrienes.
Composition
Xofyl 400 tablet: Each film coated tablet contains Doxophylline INN 400 mg. Xofyl 200 tablet: Each film coated tablet contains Doxophylline INN 200 mg.
Indications And Uses
Xofyl (Doxophylline) is used to treat asthma, COPD and bronchospasm.
Dosage And Administration
Adult: 400 mg (1 tablet) daily in the evening. However, in certain cases, 400 mg twice daily is recommended on the basis of the clinical response. Doses as high as 1200 mg/day (400 mg 3 times daily) may also be prescribed. Children (above 6 years of age): The recommended dosage of Doxophylline is 6 mg/kg twice daily. The dose may be increased up to 18 mg/kg daily on the basis of clinical response.
Side Effect
After administration, occasionally nausea, vomiting, headache may occur.
Precaution
The half-life of xanthine derivative is influenced by a number of variables. It may be prolonged in patients with liver disease, congestive heart failure and in those patients taking certain other drugs (erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol and anti-flu vaccine). In these cases, a lower dose of Doxophylline may be needed. Phenytoin and other anticonvulsants may cause shorter mean half-life and in these cases higher doses of Doxophylline may be needed.
Use In Pregnancy Lactation
Animal reproduction studies indicate that Doxophylline does not cause fetal harm when administered to pregnant animals nor can affect reproduction capacity. However, since there is limited experience in human during pregnancy, Doxophylline should be given to pregnant women only if clearly needed. Doxophylline is contraindicated in nursing mothers.
Drug Interactions
Doxophylline should not be administered together with other xanthine derivatives. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant therapy with erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, ranitidine, propranolol and anti-flu vaccine may decrease the hepatic clearance of xanthines causing an increase in blood levels.
Storage
Store below 25C and dry place, protect from light.
Contraindications
Doxophylline is contraindicated in individuals who have shown hypersensitivity to its components. It is also contraindicated in patients with acute myocardial infarction and hypotension.
How Supplied
Xofyl 400 tablet: Each box contains 3 x 10's tablet in alu-alu blister pack. Xofyl 200 tablet: Each box contains 5 x 10's tablet in alu-alu blister pack.