Amela is an US-FDA approved drug for treating Melasma. It is a combination of three active ingredients. Fluocinolone Acetonide is a synthetic fluorinated corticosteroid that reduces inflammation. Hydroquinone is classified therapeutically as a depigmenting agent and interrupts one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. Tretinoin is a metabolite of Vitamin A is classified therapeutically as a keratolytic. It works by increasing the skin cell turnover rate, which helps exfoliate the skin.